Text S1: Supplementary Methods for “dPeak: High Resolution Identification of Transcription Factor Binding Sites from PET and SET ChIP-Seq Data”
نویسندگان
چکیده
1 Department of Statistics, University of Wisconsin, Madison, WI, U.S.A. 2 Department of Biomolecular Chemistry, University of Wisconsin, Madison, WI, U.S.A. 3 Department of Biochemistry, University of Wisconsin, Madison, WI, U.S.A. 4 Great Lakes Bioenergy Research Center, University of Wisconsin, Madison, WI, U.S.A. 5 Department of Bacteriology, University of Wisconsin, Madison, WI, U.S.A. 6 Department of Biostatistics and Medical Informatics, University of Wisconsin, Madison, WI, U.S.A. # Current address: Department of Biostatistics, Yale University, New Haven, CT, U.S.A.
منابع مشابه
dPeak: High Resolution Identification of Transcription Factor Binding Sites from PET and SET ChIP-Seq Data
Chromatin immunoprecipitation followed by high throughput sequencing (ChIP-Seq) has been successfully used for genome-wide profiling of transcription factor binding sites, histone modifications, and nucleosome occupancy in many model organisms and humans. Because the compact genomes of prokaryotes harbor many binding sites separated by only few base pairs, applications of ChIP-Seq in this domai...
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MOTIVATION Chromatin immunoprecipitation coupled to next-generation sequencing (ChIP-seq) is widely used to study the in vivo binding sites of transcription factors (TFs) and their regulatory targets. Recent improvements to ChIP-seq, such as increased resolution, promise deeper insights into transcriptional regulation, yet require novel computational tools to fully leverage their advantages. ...
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Mapping genome-wide binding sites of all transcription factors (TFs) in all biological contexts is a critical step toward understanding gene regulation. The state-of-the-art technologies for mapping transcription factor binding sites (TFBSs) couple chromatin immunoprecipitation (ChIP) with high-throughput sequencing (ChIP-seq) or tiling array hybridization (ChIP-chip). These technologies have l...
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